Ⅰ.Endocrinology
1.Lipid Effects of Endocrine Medications
Various alterations of lipid homeostasis have a significant role in the pathophysiology of the artherosclerotic process. The effects of usual lipid-lowering agents such as statins, fibrates, or niacin are well known, but other endocrine therapeutic agents could also affect the blood levels of various lipoproteins and, in turn, influence atheroma formation. In this review, we attempt to summarize the effect of several hormonal and non-hormonal endocrine agents on lipid metabolism, including insulin, thyroid hormone, sex hormones, glucocorticoids, growth hormone, and several anti-diabetic agents

Ⅱ.Gastroenterology
1. Comparison of semi-automated and manual methods to measure the volume of liver tumours on MDCT images
Dubus L et al. – To retrospectively compare semi–automated and manual volume measurements of malignant liver tumours and inter– and intra–observer variability using commercially available software. In the study, semi–automated volume analysis of malignant liver tumours correlated well with the manual method. Furthermore, the semi–automated volume analysis was significantly quicker

Ⅲ.Allergy/Immunology
1. A pathway-based approach to find novel markers of local glucocorticoid treatment in intermittent allergic rhinitis
Wang H et al. – Glucocorticoids (GCs) may affect the expression of hundreds of genes in different cells and tissues from patients with intermittent allergic rhinitis (IAR). It is a formidable challenge to understand these complex changes by studying individual genes. In this study, the authors aimed to identify pathways affected by local GC treatment and examine if those pathways could be used to find novel markers of local GC treatment in nasal fluids from patients with IAR. Pathway–based analyses of genomic and proteomic high–throughput data can be used as a complementary approach to identify novel potential markers of GC treatment in IAR

2.The role of penicillin in benign skin rashes in childhood: A prospective study based on drug rechallenge
Delayed-onset urticarial or maculopapular rashes are frequently observed in children treated with β-lactams. Many are labeled "allergic" without reliable testing.In this situation, β-lactam allergy is clearly overdiagnosed because the skin rash is only rarely reproducible (6.8%) by a subsequent challenge. Viral infections may be an important factor in many of these rashes. OCTs were positive in a minority of intradermal skin test–positive subjects. Patch testing and blood allergy testing provided no useful information. OCTs should be considered in all children who develop a delayed-onset urticarial or maculopapular rash during treatment with a β-lactam

Ⅳ. Hematology/Oncology
1. Desai et al: Choriocarcinoma is a highly malignant tumor of trophoblastic origin. Most cases present within one year of the antecedent pregnancy (molar or non-molar). However, very rarely, choriocarcinoma can develop from germ cells or from dedifferentiation of endometrial carcinoma into choriocarcinoma. This article concerns a case of choriocarcinoma developing 38 years after the patient's last pregnancy and 23 years after menopause

2. Management of Anemia in Heart failure
Stamos et al: Anemia is a relatively common finding in heart failure. Anemia in heart failure patients has been independently associated with reduced exercise tolerance, increased heart failure hospitalizations and increased all–cause mortality. Despite initial studies indicating a possible beneficial effect of erythropoiesis–stimulating agents in the treatment of anemic heart failure patients, clinical trial data, to date, have failed to show convincing evidence for morbidity or mortality benefit, and information on the long–term safety is lacking. Ongoing large–scale trials will have the potential to provide such information in the future